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ABSTRACT Biological anthropologists have long engaged in qualitative data analysis (QDA), though such work is not always foregrounded. In this article, we discuss the role of rigorous and systematic QDA in biological anthropology and consider how it can be understood and advanced. We first establish what kinds of qualitative data and analysis are used in biological anthropology. We then review the ways QDA has been used in six subfields of biological anthropology: primatology, human biology, paleoanthropology, dental and skeletal biology, bioarchaeology, and anthropological genetics. We follow that with an overview of how to use QDA methods: three simple QDA methods (i.e., word‐based analysis, theme analysis, and coding) and three QDA approaches for model‐building and model‐testing (i.e., content analysis, semantic network analysis, and grounded theory). With this foundation in place, we discuss how QDA can support transformative research in biological anthropology—emphasizing the valuable role of QDA in inductive and community‐based research. We discuss how QDA supports transformative research using mixed‐methods research designs, participatory action research, and abolition and Black feminist research. Finally, we consider how to close a QDA project, reflecting on the logistics, ethics, and limitations of qualitative data sharing, including how researchers can use the CARE Principles (Collective Benefit, Authority to Control, Responsibility, and Ethics) to support Indigenous data sovereignty.